Curr Opin Immunol. 1999 Aug;11(4):466-74.

Host genetic influences on HIV-1 pathogenesis.

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Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA. nmichael@pasteur.hjf.org

Abstract

Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.

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