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Acta Psychiatr Scand. 1999 Jul;100(1):67-75.

Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration.

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  • 1Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

OBJECTIVE:

The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation.

METHOD:

Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC.

RESULTS:

After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate.

CONCLUSION:

Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

PMID:
10442442
[PubMed - indexed for MEDLINE]
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