Evaluation of the effects of desmopressin in acute ureteral obstruction

Urol Int. 1999;62(1):8-11. doi: 10.1159/000030346.

Abstract

Objective: To evaluate the effects of desmopressin on pressure values inside the pelvis and ureter of the rat following acute obstruction.

Materials and methods: By means of a microsurgical technique, 24 male Wistar rats were submitted to ureteral obstruction; pressure inside the ureter was recorded using a cannula and a micrometric glass column. In the treatment group (14 animals) 6 mg/kg of desmopressin were administered 30 min before the beginning of the experiment.

Results: Rats pretreated with desmopressin showed a statistically significant reduction in mean intraureteral pressure following acute obstruction (p = 0.05).

Conclusions: In Wistar rats desmopressin demonstrated a powerful antidiuretic effect, reducing the intraureteral pressure. The experimental model is useful for a better understanding of physiopathology of renal colic and acute obstruction.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Animals
  • Deamino Arginine Vasopressin / pharmacology*
  • Disease Models, Animal
  • Male
  • Muscle Contraction / drug effects
  • Pelvis / physiopathology
  • Pressure
  • Rats
  • Rats, Wistar
  • Renal Agents / pharmacology*
  • Reproducibility of Results
  • Ureter / drug effects*
  • Ureter / physiopathology
  • Ureteral Obstruction / physiopathology*
  • Urodynamics / drug effects

Substances

  • Renal Agents
  • Deamino Arginine Vasopressin