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Am J Otol. 1999 Jul;20(4):416-20.

The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion.

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  • 1Department of Otolaryngology, Geisinger Medical Center, Danville, Pennsylvania 17822, USA.

Abstract

OBJECTIVE:

This study aimed to evaluate the effectiveness of prophylactic ciprofloxacin drops in decreasing the incidence of otorrhea after tympanostomy tube insertion.

STUDY DESIGN:

The study design was a single-blind, randomized clinical trial.

SETTING:

The study was conducted at a tertiary care referral center.

PATIENTS:

One hundred fifty-four patients aged 6 months to 14 years undergoing tympanostomy tube insertion participated.

INTERVENTION:

For each subject, one ear was randomly assigned to receive topical ciprofloxacin, placed in the middle and external ear after surgery, while the contralateral ear served as a control.

MAIN OUTCOME MEASURE:

Posttympanostomy otorrhea occurring during the period from 24 hours after surgery until 2 weeks after surgery was measured.

RESULTS:

Topical ciprofloxacin application after tympanostomy tube insertion was associated with a significantly lower incidence of early posttympanostomy otorrhea. The rates of otorrhea for control and treatment ears were 9.1% and 3.9%, respectively (p = 0.029).

CONCLUSIONS:

The topical administration of a single dose of ciprofloxacin solution after surgery is an effective treatment for the prevention of early posttympanostomy otorrhea.

PMID:
10431879
[PubMed - indexed for MEDLINE]
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