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Trends Genet. 1999 Aug;15(8):291-4.

Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes.

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  • 1Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6.


Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.

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