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Immunol Today. 1999 Aug;20(8):356-61.

GPI-microdomains: a role in signalling via immunoreceptors.

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  • 1Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague 4, V denská 1083, Czech Republic. horejsi@biomed.cas.cz


Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.

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