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Immunol Today. 1999 Aug;20(8):351-6.

CTL granules: evolution of vesicles essential for combating virus infections.

Author information

  • 1Austin Research Institute, Studley Road, Heidelberg 3084, Australia. j.trapani@ari.unimelb.edu.au

Abstract

Viral strategies for escaping apoptosis have co-evolved with the immune system, resulting in a complex balance of pro- and anti-apoptotic forces in virus-infected cells under attack by cytotoxic T lymphocytes (CTLs). Here, Joseph Trapani and colleagues argue that CTL cytolytic granules are the principal apoptotic means of eliminating viruses and possess multiple independent mechanisms to counter the viral anti-apoptotic machinery.

PMID:
10431154
[PubMed - indexed for MEDLINE]
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