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FEBS Lett. 1999 Jul 16;455(1-2):170-4.

Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues.

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  • 1Clore Laboratory, University of Buckingham, UK. valur.emilsson@buckingham.ac.uk

Abstract

Leptin concentrations are elevated in the majority of obese individuals raising the possibility that leptin resistance contributes to their obesity. Peripheral leptin administration for 48 h caused a several-fold increase in mRNA encoding the suppressors of cytokine signaling SOCS-3 and CIS in hypothalamus and peripheral tissues. Paradoxically, CIS and SOCS-3 mRNAs are also elevated in the leptin-deficient ob/ob mouse. Forced expression of CIS in insulinoma cells prevented transactivation mediated by leptin. Thus tissues continuously exposed to leptin and/or other factors associated with obesity accumulate excessive amounts of SOCS-3 and CIS which could provide a potential mechanism for leptin resistance.

PMID:
10428495
[PubMed - indexed for MEDLINE]
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