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Fertil Steril. 1999 Jul;72(1):1-7.

Effect of diethylstilbestrol on reproductive function.

Author information

  • 1Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Ohio 44195, USA. goldbej@cesmtp.ccf.org

Abstract

OBJECTIVE:

To review the effects of in utero exposure to diethylstilbestrol (DES) on müllerian development and subsequent reproductive function.

DESIGN:

The literature on DES and reproductive function was reviewed and summary data are presented. The studies were identified through the computerized MEDLINE database and a manual search of relevant bibliographies.

RESULT(S):

In utero exposure to DES resulted in reduced fertility and increased rates of ectopic pregnancy, spontaneous abortion, and preterm delivery.

CONCLUSION(S):

An understanding of the reproductive performance of women who were exposed to DES in utero is useful for counseling these patients regarding their risks and treatment options.

PMID:
10428139
[PubMed - indexed for MEDLINE]
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