Cell. 1999 Jul 23;98(2):181-91.

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction.

Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF.

Source

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

Abstract

The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have normal steady-state hematocrit. Here we show that Stat5 is essential for the high erythropoietic rate during fetal development. Stat5a-/-5b-/- embryos are severely anemic; erythroid progenitors are present in low numbers, show higher levels of apoptosis, and are less responsive to Epo. These findings are explained by a crucial role for Stat5 in EpoR's antiapoptotic signaling: it mediates the immediate-early induction of Bcl-X(L) in erythroid cells through direct binding to the Bcl-X promoter.

PMID:: 10428030; [PubMed - indexed for MEDLINE]

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a dir...
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction.
Cell. 1999 Jul 23 ;98(2):181-91.

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