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    Science. 1999 Jul 30;285(5428):760-3.

    Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.

    Mazmanian SK, Liu G, Ton-That H, Schneewind O.

    Source

    Department of Microbiology and Immunology, UCLA School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

    Abstract

    Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant defective in the anchoring of surface proteins was isolated and shown to carry a mutation in the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein specified by srtA, sortase, may be a useful target for the development of new antimicrobial drugs.

    PMID:
    10427003
    [PubMed - indexed for MEDLINE]
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