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J Orofac Pain. 1999 Spring;13(2):83-8.

Trazodone in burning mouth pain: a placebo-controlled, double-blind study.

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  • 1Institute of Dentistry, Turku University, Finland.

Abstract

AIMS:

An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain.

METHODS:

Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks.

RESULTS:

There were no significant differences between the groups in treatment effects for pain or pain-related symptoms. Seven patients in the trazodone group and 2 in the placebo group failed to complete the trial because of side effects. The most common side effects were dizziness and drowsiness.

CONCLUSION:

In this controlled trial, trazodone failed to relieve burning mouth pain.

PMID:
10425979
[PubMed - indexed for MEDLINE]
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