Biochem Biophys Res Commun. 1999 Aug 2;261(2):456-8.

PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.

Pelton PD, Zhou L, Demarest KT, Burris TP.

Source

Endocrine Therapeutics, R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, 08869, USA.

Abstract

The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs). PPARgamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation. PPARgamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages. Activation of PPARgamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions. We report that both natural and synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1. These data suggest that PPARgamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in adipocytes.

PMID:: 10425206; [PubMed - indexed for MEDLINE]

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