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1: Phytochemistry. 1999 Aug;51(7):899-902.Click here to read Links

A chromene and prenylated benzoic acid from Piper aduncum.

Baldoqui DC, Kato MJ, Cavalheiro AJ, Bolzani Vda S, Young MC, Furlan M.

Instituto de Química, Universidade Estadual Paulista, Araraquara, SP, Brazil.

In addition to nerolidol, 2',6'-dihydroxy-4'-methoxydihydrochalcone, methyl 2,2-dimethyl-8-(3'-methyl-2'-butenyl)-2H-1-chromene-6-carboxylate, methyl 2,2-dimethyl-2H-1-chromene-6-carboxylate and methyl 8-hydroxy-2,2-dimethyl-2H-1-chromene-6-carboxylate, two new natural products were isolated from the leaves of Piper aduncum, 2,2-dimethyl-2H-1-chromene-6-carboxylic acid and 3-(3',7'-dimethyl-2',6'-octadienyl)-4-methoxybenzoic acid. The structures of the isolates were established based on analysis of spectroscopic data, including ES-MS. The DNA-damaging activity of the isolated compounds was also investigated against mutant strains of Saccharomyces cerevisiae.

PMID: 10423861 [PubMed - indexed for MEDLINE]