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Vnitr Lek. 1998 Nov;44(11):661-4.

[Tissue plasminogen activator and diabetes mellitus].

[Article in Slovak]

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  • 1I. interná klinika MFN, Martin.


tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.

[PubMed - indexed for MEDLINE]
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