Format

Send to:

Choose Destination
See comment in PubMed Commons below
Infect Immun. 1999 Aug;67(8):4280-4.

Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis.

Author information

  • 1Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D.C. 20007-2197, USA.

Abstract

Deletion of both alleles of the Candida albicans CaHK1 gene, which causes cells to flocculate when grown at pH 7.5, a pH comparable to that of mammalian blood, abolishes the ability of the yeast to establish a successful infection in a murine model of hematogenously disseminated candidiasis. Within 72 h all mice inoculated with the parental C. albicans strain had died. The mice infected with either the heterozygote or revertant strain, either of which harbors only one functional CaHK1 allele, also succumbed to the infection, although survivors were observed for up to 16 days postinfection. However, mice inoculated with the Deltacahk1 null strain survived for the course of the infection. These results indicate that CaHK1 is required for the virulence of C. albicans in a murine model of hematogenously disseminated candidiasis. In contrast, CaHK1 is not required for the virulence of C. albicans in a rat model of vaginal candidiasis.

PMID:
10417206
[PubMed - indexed for MEDLINE]
PMCID:
PMC96739
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk