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Mol Biochem Parasitol. 1999 Jun 25;101(1-2):23-32.

Karyotype and synteny among the chromosomes of all four species of human malaria parasite.

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  • 1Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA. carltonj@mail.vetmed.ufl.edu


The karyotype and chromosomes of the human malaria parasite Plasmodium falciparum have been well characterized in recent years. Here we present karyotype maps of the three other human malaria species, P. vivax, P. malariae and P. ovale. Chromosomes of these species were found to be of significantly higher molecular weight than those of P. falciparum. Some 14 P. vivax chromosomes were distinguishable, and 12-14 P. malariae and P. ovale chromosomes. The chromosome location of 15 genes, known to be present within five synteny groups between P. falciparum and the rodent malarias, were analyzed, and four of these synteny groups were found to be conserved between all of the human malaria species. In addition, a more detailed genome map of P. vivax was made using ten housekeeping and antigen genes. These data represent the first karyotype maps of all species of malaria which infect man.

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