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Science. 1999 Jul 16;285(5426):422-4.

Different trajectories of parallel evolution during viral adaptation.

Author information

  • 1Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA. hwichman@uidaho.edu

Abstract

The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotide changes genomewide in each replicate. At least 96 percent of the amino acid substitutions appeared to be adaptive, and half the changes in one line also occurred in the other. However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation.

PMID:
10411508
[PubMed - indexed for MEDLINE]
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