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Dermatol Clin. 1999 Jul;17(3):657-66, x.

Use of the polymerase chain reaction in the evaluation of cutaneous T-cell infiltrates.

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  • 1Dermatopathology Service, Stanford University School of Medicine, California, USA.


Histologic evaluation of suspected cutaneous T-cell neoplasia is challenging. There is significant overlap with features of benign condition, and neoplastic cells often occur in a reactive background. Recently, molecular techniques using paraffin-embedded tissue have been applied to the diagnosis of cutaneous T-cell infiltrates. These methods are useful for determining whether a clonal population of T-cells is present. The advantages and limitation of molecular diagnostic methods in the diagnosis of cutaneous T-cell infiltrates are discussed.

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