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1: Neurology. 1999 Jul 13;53(1):220-2.Click here to read Links
Comment in:
Neurology. 2000 Apr 11;54(7):1545-6.

Lethal capillary leak syndrome after a single administration of interferon beta-1b.

Schmidt S, Hertfelder HJ, von Spiegel T, Hering R, Harzheim M, Lassmann H, Deckert-Schlüter M, Schlegel U.

Department of Neurology, University of Bonn, Germany.

Interferon beta-1b (IFNbeta-1b) is a potent immunomodulatory drug in the treatment of MS. We report a lethal capillary leak syndrome after the administration of IFNbeta-1b in a patient with disseminated white matter disease, monoclonal gammopathy, and acquired C1 inhibitor (C1-INH) deficiency. IFNbeta-1b may cause a transient release of proinflammatory cytokines finally resulting in an uninhibited activation of the complement cascade in patients with C1-INH deficiency.

PMID: 10408566 [PubMed - indexed for MEDLINE]

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