Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Comp Pathol. 1999 Aug;121(2):117-25.

Repeated oral dosing with Listeria monocytogenes in mice as a model of central nervous system listeriosis in man.

Author information

  • 1Departamento de Patología y Producción Animales (Histología y Anatomía Patológica), Facultad de Veterinaria, Universidad Autónoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

Abstract

Human listeriosis is a food-borne disease of immunosuppressed or previously healthy adults. The repeated oral administration of a sublethal dose (5x10(9)colony-forming units) of Listeria monocytogenes for 7 or 10 consecutive days led to the development of severe central nervous system (CNS) lesions in 25% of experimental mice. Histopathological examination of the brain revealed rhombencephalitis and ventriculitis as two distinct inflammatory patterns, resembling those seen in human listeriosis. This model would seem to be potentially useful for research on pathogenesis, predisposing factors and therapy in CNS listeriosis in man. 1999 W.B. Saunders and Company Ltd.

PMID:
10405304
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk