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J Am Geriatr Soc. 1999 Jul;47(7):799-803.

The relation between cortisol excretion and fractures in healthy older people: results from the MacArthur studies-Mac.

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  • 1Division of Geriatrics, UCLA School of Medicine, Los Angeles, California 90095-1687, USA.

Abstract

BACKGROUND:

In persons with depression, higher urinary cortisol is associated with lower bone mineral density.

OBJECTIVE:

To examine the relation between urinary free cortisol (UFC) and fractures.

SETTING:

Community-based samples from Durham, NC, East Boston, MA, and New Haven, CT.

PARTICIPANTS:

684 men and women, aged 70 to 79 at baseline, who were part of the MacArthur Study of Successful Aging.

DESIGN:

Cohort study. Participants with previous history of fractures at baseline were excluded.

MEASURES:

The primary exposure variable was overnight (8:00 p.m. to 8:00 a.m.) UFC (microg/g creatinine) at baseline (1988). Outcomes were self-reported hip, arm, spine, wrist, or other fracture during the follow-up period (1988-1995). Covariates were baseline age, gender, race, body mass index, current physical activity, lower extremity strength, depression subscale of the Hopkins Symptom Checklist, and current use of cigarettes and alcohol.

ANALYSIS:

Logistic regression was used to predict the occurrence of incident fractures (1988-1995) as a function of quartiles of baseline UFC. Models were adjusted for age, gender, and race and were also multiply adjusted for the remaining covariates listed above. Gender-stratified models and models that excluded corticosteroid users were also run.

RESULTS:

In multiply adjusted models, higher baseline levels of UFC were significantly associated with incident fractures. Odds of fracture (95% Confidence Intervals) for increasing quartiles of baseline UFC, multiply adjusted, were: 2.28 (.91, 5.77); 3.40 (1.33, 8.69); 5.38 (1.68, 17.21). Results were not materially influenced by exclusion of persons using corticosteroids.

CONCLUSIONS:

Higher baseline UFC is an independent predictor of future fracture.

PMID:
10404922
[PubMed - indexed for MEDLINE]
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