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J Affect Disord. 1999 Jun;53(3):279-83.

Olanzapine in the treatment of adolescent acute mania: a report of seven cases.

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  • 1Division of Child and Adolescent Psychiatry, Children's Hospital Medical Center, Cincinnati, OH, USA.

Abstract

BACKGROUND:

Clozapine may be effective in adults and adolescents with treatment-resistant bipolar disorder. Olanzapine has a receptor affinity profile similar to that of clozapine.

METHODS:

The responses of seven consecutive adolescents (ages 12-17) with DSM-IV bipolar disorder, manic episode, treated with olanzapine were evaluated. Response to olanzapine was rated as marked, moderate, minimal, none or worse.

RESULTS:

Five (71%) adolescents showed a marked or moderate response. The mean+/-SD olanzapine dose was 0.146+/-0.086 mg/kg/day (11+/-6 mg/day).

CONCLUSION:

Olanzapine may have antimanic effects in some adolescents with acute mania. Controlled studies of olanzapine in adolescent bipolar disorder appear to be warranted.

PMID:
10404715
[PubMed - indexed for MEDLINE]
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