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Science. 1999 Jul 9;285(5425):260-3.

BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.

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  • 1Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.

Abstract

The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

PMID:
10398604
[PubMed - indexed for MEDLINE]
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