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Curr Opin Neurobiol. 1999 Jun;9(3):288-92.

Regulation of back-propagating action potentials in hippocampal neurons.

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  • 1Division of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030-3498, USA.


Protein kinase C has recently been shown to modulate the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Moreover, dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase. The electrical signalling ability of these dendrites is thus highly regulated by a number of neurotransmitters and second-messenger systems.

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