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Curr Opin Cell Biol. 1999 Jun;11(3):352-7.

mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription.

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  • 1Department of Cell Biology, Biozentrum University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland. minvielle@ubaclu.unibas.ch


Eukaryotic mRNA precursors are processed at their 3' ends by a coupled cleavage/polyadenylation reaction. In recent years, most of the factors involved in 3'-end processing have been identified and evidence has been presented for the coupling of mRNA 3'-end formation to capping, splicing and transcription. These links are important for the quality control of the mRNA during synthesis.

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