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Curr Opin Cell Biol. 1999 Jun;11(3):363-71.

hnRNP complexes: composition, structure, and function.

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  • 1Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA.

Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are predominantly nuclear RNA-binding proteins that form complexes with RNA polymerase II transcripts. These proteins function in a staggering array of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover. Recent studies suggest that several fundamental characteristics of hnRNPs account for their involvement in multiple regulatory pathways.

PMID:
10395553
[PubMed - indexed for MEDLINE]
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