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J Reprod Med. 1999 Jun;44(6):535-42.

Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors.

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  • 1Saint Louis University School of Medicine, Missouri, USA.

Abstract

OBJECTIVE:

To review the literature describing female orgasmic disorder and impaired sexual desire disorder by selective serotonin reuptake inhibitors (SSRIs) and their treatment, including the use of sildenafil.

STUDY DESIGN:

Literature reviews of all available published articles on this topic from 1989 to 1996 were done. This paper also includes a sample case of a 38-year old woman who suffers from fluoxetine-induced arousal and orgasmic disturbance.

RESULTS:

Treatment approaches include the use of "antidotes," such as cyproheptadine, yohimbine, amantadine, granisetron and ginkgo biloba. This article also reports a case of successful female use of sildenafil, which was released by the Food and Drug Administration in March 1998 for erectile dysfunction in men.

CONCLUSION:

Sildenafil is beneficial in reversing female sexual dysfunction induced by SSRIs. This paper also discusses sildenafil's action in the background of nitric oxide and cyclic guaninosine monophosphate in penile/clitoral erection.

PMID:
10394548
[PubMed - indexed for MEDLINE]
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