Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biol Psychiatry. 1999 Jul 1;46(1):119-24.

Schizophrenia and the influenza epidemics of 1957 in Japan.

Author information

  • 1Department of Neuropsychiatry, Kochi Medical School, Japan.

Abstract

BACKGROUND:

We tested the hypothesis that the exposure to an influenza epidemic during the second trimester of gestation is associated with an increased risk of later development of schizophrenia.

METHODS:

There were three influenza epidemics (A/B mixed type, the first A2 type and the second A2 type) in 1957 in Kochi, Japan. We compared the risk of developing schizophrenia in birth cohorts exposed to these three influenza epidemics during gestation with that in birth cohorts not exposed. To identify subjects who had developed schizophrenia, we surveyed patients with schizophrenia who received medical care at all psychiatric institutions in Kochi prefecture.

RESULTS:

There is a pattern that schizophrenic births increase twice or more among female subjects who were exposed to each of three influenza epidemics in the fifth month of gestation. The increase in the female births exposed to the second A2 epidemic was significant (relative risk 2.86, 95% confidence interval 1.37-5.26). This pattern across the three epidemics was not observed in male subjects.

CONCLUSIONS:

Prenatal exposure to an influenza epidemic during the second trimester increased the risk of later development of schizophrenia in female births.

PMID:
10394481
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk