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Skin Pharmacol Appl Skin Physiol. 1999 May-Jun;12(3):132-8.

Successful treatment of oxidative stress in vitiligo.

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  • 1Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK.


Patients with vitiligo have low catalase levels in their involved and uninvolved epidermis in association with high levels of hydrogen peroxide (H2O2). H2O2 has been confirmed for the first time in vivo using Fourier Transform Raman spectroscopy. A topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H2O2 in vitiligo. This approach leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder.

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