Science. 1999 Jul 2;285(5424):113-6.

Positive selection of natural autoreactive B cells.

Hayakawa K, Asano M, Shinton SA, Gui M, Allman D, Stewart CL, Silver J, Hardy RR.

Source

Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. K_Hayakawa@fccc.edu

Abstract

Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.

PMID:: 10390361; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Related citations

Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. [J Exp Med. 2003]
Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development.
Hayakawa K, Asano M, Shinton SA, Gui M, Wen LJ, Dashoff J, Hardy RR. J Exp Med. 2003 Jan 6; 197(1):87-99.
Review B-1 cells: orthodox or conformist? [Curr Opin Immunol. 2000]
Review B-1 cells: orthodox or conformist?
Su I, Tarakhovsky A. Curr Opin Immunol. 2000 Apr; 12(2):191-4.
B cell positive selection by soluble self-antigen. [J Immunol. 2002]
B cell positive selection by soluble self-antigen.
Julien S, Soulas P, Garaud JC, Martin T, Pasquali JL. J Immunol. 2002 Oct 15; 169(8):4198-204.
Review A model for autoantigen induction of natural antibody producing B-1a cells. [Curr Top Microbiol Immunol. 2000]
Review A model for autoantigen induction of natural antibody producing B-1a cells.
Berland R, Wortis HH. Curr Top Microbiol Immunol. 2000; 252:49-55.
Review B-1 B cells: development, selection, natural autoantibody and leukemia. [Curr Opin Immunol. 2006]
Review B-1 B cells: development, selection, natural autoantibody and leukemia.
Hardy RR. Curr Opin Immunol. 2006 Oct; 18(5):547-55. Epub 2006 Aug 1.

See reviews... See all...

Cited by 60 PubMed Central articles

A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. [Proc Natl Acad Sci U S A. 2012]
A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells.
Miles K, Heaney J, Sibinska Z, Salter D, Savill J, Gray D, Gray M. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):887-92. Epub 2011 Dec 29.
Autoantibodies: Focus on anti-DNA antibodies. [Self Nonself. 2011]
Autoantibodies: Focus on anti-DNA antibodies.
Almqvist N, Winkler TH, Mårtensson IL. Self Nonself. 2011 Jan; 2(1):11-18. Epub 2011 Jan 1.
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. [J Exp Med. 2011]
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway.
Kometani K, Yamada T, Sasaki Y, Yokosuka T, Saito T, Rajewsky K, Ishiai M, Hikida M, Kurosaki T. J Exp Med. 2011 Jul 4; 208(7):1447-57. Epub 2011 Jun 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Positive selection of natural autoreactive B cells.
Positive selection of natural autoreactive B cells.
Science. 1999 Jul 2 ;285(5424):113-6.

PubMed
Croup.
Croup.
Clin Evid. 2004 Dec ;(12):401-26.

PubMed
Can family history be used as a tool for public health and preventive medicine?
Can family history be used as a tool for public health and preventive medicine?
Genet Med. 2002 Jul-Aug ;4(4):304-10.

PubMed
Severe complications of inflammatory bowel disease.
Severe complications of inflammatory bowel disease.
Med Clin North Am. 2008 May ;92(3):671-86, ix.

PubMed
Comparison of visual function following implantation of Acrysof Natural intraocu...
Comparison of visual function following implantation of Acrysof Natural intraocular lenses with conventional intraocular lenses.
Clin Experiment Ophthalmol. 2007 Mar ;35(2):152-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Positive selection of natural autoreactive B cells.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Cited by 60 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information