Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles

E C Torres-Santos; J M Rodrigues Jr; D L Moreira; M A Kaplan; B Rossi-Bergmann

doi:10.1128/AAC.43.7.1776

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles

Antimicrob Agents Chemother. 1999 Jul;43(7):1776-8. doi: 10.1128/AAC.43.7.1776.

Authors

E C Torres-Santos¹, J M Rodrigues Jr, D L Moreira, M A Kaplan, B Rossi-Bergmann

Affiliation

¹ Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.

MeSH terms

Animals
Antiparasitic Agents / administration & dosage*
Chalcone / administration & dosage
Chalcone / analogs & derivatives*
Chalcones
Drug Delivery Systems
Female
Leishmania / drug effects*
Leishmaniasis / drug therapy
Mice
Mice, Inbred BALB C
Polyesters / administration & dosage*

Substances

2',6'-dihydroxy-4'-methoxychalcone
Antiparasitic Agents
Chalcones
Polyesters
poly(lactide)
Chalcone