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Can Fam Physician. 1999 Jun;45:1451-3.

Safe use of valproic acid during pregnancy.

Author information

  • 1University of Toronto.

Abstract

QUESTION:

I have an epileptic patient who plans pregnancy. It took us years to control her seizures, and valproic acid seems to be the only way to control them. What is the risk to her fetus?

ANSWER:

Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid. About 1% to 2% of exposed fetuses suffer adverse effects.

PMID:
10386205
[PubMed - indexed for MEDLINE]
PMCID:
PMC2328449
Free PMC Article
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