Experimental studies on lignans and cancer. [Baillieres Clin Endocrinol Metab. 1998]

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1: Baillieres Clin Endocrinol Metab. 1998 Dec;12(4):691-705.Links

Experimental studies on lignans and cancer.

Thompson LU.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.

Mammalian lignans are produced from plant precursors such as secoisolariciresinol diglycoside (SDG) and matairesinol via the action of bacteria in the human or animal colon. While precursors are found in many plant foods, flaxseed is the richest source of SDG and was therefore used as a model to determine the anti-cancer effects of lignans. This paper reviews the experimental studies in animals and humans demonstrating the anti-cancer effects of flaxseed and its SDG as well as other studies relevant to the clinical use of lignans, such as those on their food sources, bio-availability and safety.

PMID: 10384820 [PubMed - indexed for MEDLINE]

Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed.
J Nutr. 1996 Aug; 126(8):2012-9.

[J Nutr. 1996]
Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures.
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[Carcinogenesis. 1999]
Flaxseed and lignans increase cecal beta-glucuronidase activity in rats.
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[Nutr Cancer. 1999]
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[Nutr Cancer. 2005]
ReviewAssessing exposure to lignans and their metabolites in humans.
J AOAC Int. 2006 Jul-Aug; 89(4):1174-81.

[J AOAC Int. 2006]
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