J Biol Chem. 1999 Jul 2;274(27):19403-10.

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z.

Source

Tularik Inc., South San Francisco, California 94080, USA.

Abstract

The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of other members of the Toll/IL-1 receptor family. We now report the identification and characterization of a novel IRAK-like molecule. In contrast to the ubiquitously expressed IRAK and IRAK-2, this new IRAK-like molecule is found mainly in cells of monomyeloic origin and is, therefore, designated IRAK-M. Although IRAK-M and IRAK-2 exhibit only a negligible autophosphorylation activity, they can reconstitute the IL-1 response in a 293 mutant cell line lacking IRAK. In addition, we show for the first time that members of the IRAK family are indispensable elements of lipopolysaccharide signal transduction. The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family.

PMID:: 10383454; [PubMed - indexed for MEDLINE]

Free full text

MeSH Terms, Substances, Secondary Source ID

MeSH Terms

Substances

Secondary Source ID

GENBANK/AF113136

LinkOut - more resources

Full Text Sources

Research Materials

Supplemental Content

Related citations

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. [Science. 1997]
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
Muzio M, Ni J, Feng P, Dixit VM. Science. 1997 Nov 28; 278(5343):1612-5.
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. [Proc Natl Acad Sci U S A. 2002]
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
Li S, Strelow A, Fontana EJ, Wesche H. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5567-72.
Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1. [Mol Cell Biol. 2001]
Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1.
Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA. Mol Cell Biol. 2001 Jul; 21(14):4544-52.
Review Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. [Mol Cell. 2003]
Review Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.
Janssens S, Beyaert R. Mol Cell. 2003 Feb; 11(2):293-302.
Review Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. [Biochim Biophys Acta. 2002]
Review Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.
Martin MU, Wesche H. Biochim Biophys Acta. 2002 Nov 11; 1592(3):265-80.

See reviews... See all...

Cited by 38 PubMed Central articles

Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome. [PLoS One. 2012]
Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.
Hulsmans M, Geeraert B, De Keyzer D, Mertens A, Lannoo M, Vanaudenaerde B, Hoylaerts M, Benhabilès N, Tsatsanis C, Mathieu C, et al. PLoS One. 2012; 7(1):e30414. Epub 2012 Jan 17.
IRAK-M regulation and function in host defense and immune homeostasis. [Infect Dis Rep. 2010]
IRAK-M regulation and function in host defense and immune homeostasis.
Hubbard LL, Moore BB. Infect Dis Rep. 2010 Jan 1; 2(1).
TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth. [Oncogene. 2011]
TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth.
Standiford TJ, Kuick R, Bhan U, Chen J, Newstead M, Keshamouni VG. Oncogene. 2011 May 26; 30(21):2475-84. Epub 2011 Jan 31.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (...
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
J Biol Chem. 1999 Jul 2 ;274(27):19403-10.

PubMed
The differential diagnosis of eosinophilic esophagitis.
The differential diagnosis of eosinophilic esophagitis.
J Clin Gastroenterol. 2000 Apr ;30(3):242-4.

PubMed
Perforating marginal ulcers after laparoscopic gastric bypass.
Perforating marginal ulcers after laparoscopic gastric bypass.
Surg Endosc. 2006 Jan ;20(1):51-4. Epub 2005 Dec 7 .

PubMed
Posterior leukoencephalopathy syndrome may not be reversible.
Posterior leukoencephalopathy syndrome may not be reversible.
Pediatr Neurol. 1999 Mar ;20(3):241-3.

PubMed
Square-stepping exercise versus strength and balance training for fall risk fact...
Square-stepping exercise versus strength and balance training for fall risk factors.
Aging Clin Exp Res. 2008 Feb ;20(1):19-24.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: