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Cancer Lett. 1999 Apr 26;138(1-2):53-9.

Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis.

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  • 1Department of Anesthesiology, University of Tsukuba, Ibaraki, Japan.


Thirty-eight oral squamous cell carcinomas (SCCs) were semi-quantitatively analyzed by immunohistochemical staining, and the relation between heme oxygenase-1 (HO-1) expression and the clinical status were correlated. High immunostaining of HO-1 was detected in lymph node metastasis negative groups (P = 0.0018) and in well-differentiated SCCs (P = 0.0016). There were no significant correlations between heme oxygenase-1 expression and other factors, such as size of the tumor, staging, age and sex. These findings further support the proposition that high heme oxygenase-1 expression in oral SCCs can be useful in identifying patients at low risk of lymph node metastasis.

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