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    Biochem J. 1999 Jul 1;341 ( Pt 1):211-6.

    Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

    Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L.

    Source

    Ludwig Institute for Cancer Research, Biomedicum, Box 595, S-751 24 Uppsala, Sweden.

    Abstract

    In this paper we demonstrate the presence of two novel in vivo autophosphorylation sites in the c-Kit/stem cell factor receptor (c-Kit/SCFR): Tyr-703 in the kinase insert and Tyr-936 in the C-terminal tail. We furthermore demonstrate that the adapter protein Grb2 is a specific binding partner for both phosphorylated Tyr-703 and phosphorylated Tyr-936, whereas the adapter protein Grb7 binds selectively to phosphorylated Tyr-936. It is shown that the association occurs through the Src homology 2 (SH2) domains of Grb2 and Grb7. Binding of Grb2 to Tyr-703 in the c-Kit/SCFR provides a link to the Ras/mitogen-activated protein kinase pathway.

    PMID:
    10377264
    [PubMed - indexed for MEDLINE]
    PMCID: PMC1220349
    Free PMC Article

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