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Infect Immun. 1999 Jul;67(7):3667-9.

Isolation and characterization of a sigB deletion mutant of Staphylococcus aureus.

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  • 1SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania, USA.

Abstract

The sigB gene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mutant showed no reduction in virulence.

PMID:
10377157
PMCID:
PMC116562
[PubMed - indexed for MEDLINE]
Free PMC Article
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