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Infect Immun. 1999 Jul;67(7):3649-52.

Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture.

Author information

  • 1Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Abstract

A Candida albicans efg1 cph1 double mutant is nonfilamentous under standard laboratory conditions and avirulent in mice. However, this mutant produced filaments in the tongues of immunosuppressed gnotobiotic piglets and when embedded in agar, demonstrating that an Efg1p- and Cph1p-independent pathway for promotion of filamentous growth exists.

PMID:
10377153
[PubMed - indexed for MEDLINE]
PMCID:
PMC116558
Free PMC Article

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