Send to

Choose Destination
See comment in PubMed Commons below
Alcohol Clin Exp Res. 1999 May;23(5):930-3.

Acetaldehyde-mediated collagen regulation in hepatic stellate cells.

Author information

  • 1Mount Sinai School of Medicine, New York, New York 10029, USA.


Alcohol-induced liver cirrhosis is one of the major causes of death worldwide. Strong evidence has established that ethanol's first metabolite, acetaldehyde, is highly fibrogenic and enhances the deposition of many extracellular matrix components by hepatic stellate cells. This article reviews our current knowledge of the molecular mechanisms whereby acetaldehyde induces these activities, with particular emphasis on those related to the upregulation of type I collagen.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk