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Trends Biotechnol. 1999 Jul;17(7):275-81.

Integrated pathway-genome databases and their role in drug discovery.

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  • 1Pangea Systems, 4040 Campbell Ave, Menlo Park, CA 94025, USA. pkarp@PangeaSystems.com


Integrated pathway-genome databases describe the genes and genome of an organism, as well as its predicted pathways, reactions, enzymes and metabolites. In conjunction with visualization and analysis software, these databases provide a framework for improved understanding of microbial physiology and for antimicrobial drug discovery. We describe pathway-based analyses of the genomes of a number of medically relevant microorganisms and a novel software tool that visualizes gene-expression data on a diagram showing the whole metabolic network of the microorganism.

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