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Pharmazie. 1999 May;54(5):347-51.

Synthesis of heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety as anti-HIV and anticancer drugs: Part I.

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  • 1Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt.

Abstract

Some new heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety (3-22) have been achieved by treatment of 3-amino-5,6-disubstituted-1,2,4-triazines 2a-h with some cyclic and acyclic oxygen compounds followed by heterocyclization. Structures of the products have been deduced by elemental analysis and spectral data. Significant anti-HIV and anticancer activities were observed in vitro for some members of the series, where compounds 5 and 18 showed a moderate activity.

PMID:
10368828
[PubMed - indexed for MEDLINE]
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