Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Pharmacol Sci. 1999 Jun;20(6):253-60.

Pontine regulation of pelvic viscera: pharmacological target for pelvic visceral dysfunctions.

Author information

  • 1Department of Psychiatry, Medical College of Pennsylvania and Hahnemann University, Broad and Vine Sts, Philadelphia, PA 19102, USA.

Abstract

The pathophysiology and pharmacological targets of disorders of the bladder and colon have focused predominantly on the periphery. However, these viscera are regulated by the CNS, which, in turn, must integrate their functions with compatible behaviours. This review focuses on the role of the pontine micturition centre, Barrington's nucleus, as a key to this integration. Through its efferent network this pontine centre links parasympathetic preganglionic neurones with forebrain-projecting nuclei, providing an anatomical substrate for coregulation of pelvic visceral and forebrain activity. Disorders characterized by multiple pelvic visceral symptoms and comorbidity with psychiatric disorders (for example functional bowel disorders) might have their roots in dysfunctions of this circuit, which could provide a novel target for pharmacological treatment.

PMID:
10366869
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk