Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Cancer. 1999 May;80(5-6):724-32.

Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts.

Author information

  • 1Department of Anatomy, Johannes Gutenberg-University Mainz, Germany.

Abstract

The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than in normal tissue. The quantitative data provide strong evidence for a characteristic vascular network determined by the tumour cells themselves.

PMID:
10360650
[PubMed - indexed for MEDLINE]
PMCID:
PMC2362271
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk