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Biol Psychiatry. 1999 Jun 1;45(11):1508-11.

Elevated plasma levels of S-100b protein in schizophrenic patients.

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  • 1Department of Neuroradiology, Ludwig Maximilian University, Munich, Germany.

Abstract

BACKGROUND:

In this study, we examined the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia.

METHODS:

We compared plasma levels of S-100b protein in 20 patients with schizophrenic psychosis and 20 age- and gender-matched healthy blood donors. Concentrations of S-100 protein were determined by microtiter-based immunofluorometric assay detecting predominantly S-100b.

RESULTS:

Mean concentrations of S-100b protein in blood were significantly (p < or = .001) higher in schizophrenic patients (0.165 +/- 0.138 microgram/L) compared to control subjects (0.054 +/- 0.031 microgram/L). Levels did not correlate with age of onset or duration of psychosis.

CONCLUSIONS:

Our findings indicate that patients with schizophrenia may suffer ongoing structural damage to cells of the central nervous system, and that the concentration of S-100b protein in plasma may help to identify clinical subgroups in schizophrenia.

PMID:
10356634
[PubMed - indexed for MEDLINE]
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