Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1999 Jun 4;284(5420):1670-2.

Genetics of mouse behavior: interactions with laboratory environment.

Author information

  • 1Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA. crabbe@ohsu.edu

Abstract

Strains of mice that show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the laboratory environment were studied in several inbred strains and one null mutant by simultaneous testing in three laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across labs. For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory.

Comment in

PMID:
10356397
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk