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    Semin Cell Dev Biol. 1999 Feb;10(1):85-91.

    GATA transcription factors and cardiac development.

    Source

    Institut de recherches cliniques de Montréal, Laboratoire de développement et différenciation cardiaques, Québec, Canada.

    Abstract

    Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.

    PMID:
    10355032
    [PubMed - indexed for MEDLINE]

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