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Trends Microbiol. 1999 May;7(5):191-5.

Pathoadaptive mutations: gene loss and variation in bacterial pathogens.

Author information

  • 1Dept of Microbiology, University of Washington, Seattle, WA 98195, USA.evs@u.washington.edu

Abstract

Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

PMID:
10354593
[PubMed - indexed for MEDLINE]
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