Clin Exp Dermatol. 1999 May;24(3):164-6.

Dermatomyositis-like eruption and leg ulceration caused by hydroxyurea in a patient with psoriasis.

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Department of Dermatology, University Hospital of Wales, Cardiff, UK. varma@cf.ac.uk

Abstract

We report the case of an elderly woman who had been on hydroxyurea for long-standing widespread psoriasis. After approximately 5 years's treatment with hydroxyurea, she developed a symmetrical dermatomyositis-like eruption on her hands, together with bilateral leg ulceration. Although similar skin eruptions have been reported after long-term hydroxyurea treatment, all of the previous patients were being treated for myeloproliferative disorders. A dermatomyositis-like eruption has not previously been reported to occur as a consequence of hydroxyurea treatment for psoriasis. Its recognition is important to prevent unnecessary investigation or treatment withdrawal.

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Clin Exp Dermatol. 2000 May;25(3):256-7.

PMID:: 10354169; [PubMed - indexed for MEDLINE]

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