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Ann Hematol. 1999 Apr;78(4):187-8.

Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.

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  • 1Department of Hematology, Hospital Xeral de Galicia, Complexo Hospitalario Universitario de Santiago de Compostela, La Coruña, Spain.


Hydroxyurea is a drug widely used to control myeloproliferative disorders, due in part to its relative lack of severe side effects. We present a case of acute interstitial pneumonitis in a patient who was treated with hydroxyurea for essential thrombocythemia. The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea. This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.

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